Optimizing antenatal corticosteroid therapy

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The metabolic effect of antenatal corticosteroid therapy.

The use of antenatal dexamethasone to mature the fetal lung in pregnancies likely to deliver before 34 weeks is almost universal. It reduces the incidence of respiratory distress syndrome in the newborn and results in an overall improvement in neonatal morbidity and mortality. Although considered to be generally safe, there are concerns about adverse maternal and fetal effects. In a series of s...

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Antenatal Corticosteroid Therapy for Fetal Maturation.

OBJECTIVES To assess the benefits and risks of antenatal corticosteroid therapy for fetal maturation. OPTIONS To administer antenatal corticosteroids or not to women at risk of preterm birth. OUTCOMES Perinatal morbidity, including: respiratory distress syndrome, intraventricular hemorrhage, infection, adrenal suppression, somatic and brain growth; perinatal mortality; and maternal morbidit...

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[Antenatal corticosteroid therapy and late preterm infant morbidity and mortality].

INTRODUCTION Late preterm infants (34-36 weeks gestation) have a morbidity rate significantly higher than those born at term. However, few interventions have been undertaken to reduce this increased morbidity and mortality. Antenatal corticosteroid administration could be an effective preventive measure. OBJECTIVE The aim of this study was to describe the morbidity associated with late premat...

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Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children.

Antenatal corticosteroid therapy substantially improves the survival rate of preterm infants, with few side effects. Higher blood pressure in adulthood has been described in several animal species after exposure to antenatal corticosteroids, but there are no similar reports in humans. The objective of the present study was to determine the relationship between exposure to antenatal corticostero...

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Methods to encourage the use of antenatal corticosteroid therapy for fetal maturation: a randomized controlled trial.

CONTEXT Antenatal corticosteroids for fetal maturation have been underused, despite evidence for their benefits in cases of preterm birth. OBJECTIVE To evaluate dissemination strategies aimed at increasing appropriate use of this therapy. DESIGN AND SETTING Twenty-seven tertiary care institutions were randomly assigned to either usual dissemination of practice recommendations (n = 14) or us...

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ژورنال

عنوان ژورنال: Seminars in Fetal and Neonatal Medicine

سال: 2019

ISSN: 1744-165X

DOI: 10.1016/j.siny.2019.05.003